A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 x 10(-11), odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 x 10(-10), OR = 1.63) and 17q12-21 (P = 1.7 x 10(-10), OR = 1.38).

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

Selmi C;LLEO De Nalda A;
2010-01-01

Abstract

A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 x 10(-11), odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 x 10(-10), OR = 1.63) and 17q12-21 (P = 1.7 x 10(-10), OR = 1.38).
2010
Odds Ratio; Alleles; Canada; Humans; European Continental Ancestry Group; Interferon Regulatory Factors; Meta-Analysis as Topic; Liver Cirrhosis; Biliary; Genome; Genome-Wide Association Study
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/13907
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