Home page

Ricerca

Aggiungi

Prodotti recenti

Ciliogenesis in Pancreatic Neuroendocrine Tumors: Insight into the Role of WDR60

: Primary cilia have emerged as key regulators in cancer biology, influencing tumor progression and therapeutic response through diverse signaling pathways. In this study, we identify WDR60, a component of the dynein-2 complex essential for retrograde intraflagellar transport, as a novel modulator of pancreatic neuroendocrine tumor (Pa-NET) behavior. Transcriptomic analysis of the GEO dataset GSE73338 revealed that WDR60 is significantly upregulated in both primary and metastatic Pa-NETs comp...

Neoadjuvant chemotherapy followed by interval surgery versus primary debulking surgery in FIGO stage III-IV epithelial ovarian cancer: A systematic review and meta-analysis

Objective: To compare survival and perioperative outcomes of Primary debulking surgery (PDS) versus neoadjuvant chemotherapy followed by interval debulking surgery (NACT-IDS) in newly diagnosed FIGO stage III-IV ovarian cancer. Primary outcomes were overall survival (OS) and progression-free survival (PFS). Data sources: MEDLINE, Embase, CENTRAL, Web of Science, Scopus, Cochrane Library, major conference proceedings (inception to July 13, 2025) STUDY SELECTION: Phase-III randomized trials com...

Durvalumab in Advanced Biliary Tract Cancer: Real‐World Data From a Large Cohort of Patients Across Multiple International Centers

Background: We recently published the first real-world multicenter and multi-institutional study of cisplatin, gemcitabine, and durvalumab in patients with advanced biliary tract cancer (BTC). Here we present an expanded patient cohort with an increased sample size and longer median follow-up. Methods: The study population included patients with advanced BTC, who received cisplatin/gemcitabine plus durvalumab at 55 centers across 12 countries in Europe, the United States, and Asia. The primar...

Genomic profiling in hepatocellular carcinoma: a real-world retrospective analysis

Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with limited molecular characterization due to reliance on radiological diagnosis. This study aims to characterize the genomic landscape of advanced HCC and assess the prognostic and predictive roles of genetic alterations (GAs). Patients and methods: This study used a de-identified nationwide (USA-based) HCC clinico-genomic database to retrospectively analyze patients with advanced HCC who received sys...

Genomic pathway alterations and their prognostic impact in biliary tract cancer: Insights from a multinational cohort treated with cisplatin, gemcitabine, and durvalumab

Background Biliary tract cancers (BTC) are aggressive malignancies with limited therapeutic options. Recent advances have integrated immunotherapy into the standard of care, yet outcomes remain heterogeneous, emphasizing the need for molecular biomarkers to guide patient selection. This study aimed to assess the prognostic impact of pathway-level genomic alterations in patients with BTC treated with first-line cisplatin, gemcitabine, and durvalumab. Methods This retrospective, multicenter stu...

Scopri

Prodotti più visti

Tips to optimize digital education in ophthalmology: Results from ESASO survey
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
Serum anti-phospholipid antibody prevalence and cardiovascular significance in the general population of the camelia study
The 10th anniversary of the Junior Members and Affiliates of the European Academy of Allergy and Clinical Immunology.
100 years of immunotherapy: the Monaco charter. under the high patronage of His Serene Highness Prince Albert II of Monaco
11C-Choline-Pet Guided Stereotactic Body Radiation Therapy for Lymph Node Metastases in Oligometastatic Prostate Cancer.
[11C]CHOLINE PET/CT SCAN PREDICTS SURVIVAL IN PROSTATE CANCER PATIENTS WITH BIOCHEMICAL FAILURE AFTER RADICAL PROSTATECTOMY.
111In-octreotide uptake in granulomatous and tumor lesions in a patient with small-cell lung cancer
1-Year Results of Paclitaxel-Coated Balloons for Long Femoropopliteal Artery Disease Evidence From the SFA-Long Study
111In-DTPA-D-Phe-1-octreotide scintigraphy of small cell lung cancer.

Prodotti più scaricati

Derazantinib (ARQ 087) in advanced or inoperable FGFR2 gene fusion-positive intrahepatic cholangiocarcinoma
In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with Autism risk genes
Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials
TNM 8th edition in thyroid cancer staging: is there an improvement in predicting recurrence?
Minimal morphological criteria for defining bone marrow dysplasia: a basis for clinical implementation of WHO classification of myelodysplastic syndromes
Type 2 Inflammation in Eosinophilic Esophagitis: From Pathophysiology to Therapeutic Targets
Patient-ventilator asynchrony in adult critically ill patients
Efficacy of Trunk Balance Exercises for Individuals With Chronic Low Back Pain: A Randomized Clinical Trial
Mini fluid chAllenge aNd End-expiratory occlusion test to assess flUid responsiVEness in the opeRating room (MANEUVER study): A multicentre cohort study
Tidal volume challenge to predict fluid responsiveness in the operating room: An observational study

Esplora il catalogo della ricerca

CINECA IRIS Institutial research information system

Ricerca

Prodotti recenti

Ciliogenesis in Pancreatic Neuroendocrine Tumors: Insight into the Role of WDR60

Neoadjuvant chemotherapy followed by interval surgery versus primary debulking surgery in FIGO stage III-IV epithelial ovarian cancer: A systematic review and meta-analysis

Durvalumab in Advanced Biliary Tract Cancer: Real‐World Data From a Large Cohort of Patients Across Multiple International Centers

Genomic profiling in hepatocellular carcinoma: a real-world retrospective analysis

Genomic pathway alterations and their prognostic impact in biliary tract cancer: Insights from a multinational cohort treated with cisplatin, gemcitabine, and durvalumab

Scopri

Tipologia

Rivista

Serie

Data di pubblicazione

Prodotti più visti

Prodotti più scaricati

31.796

pubblicazioni

911

open-access

45.353

downloads

2.381

fulltext

326

autori