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A phase Ib study of the combination of naporafenib with rineterkib or trametinib in patients with advanced and metastatic KRAS- or BRAF-mutant non-small cell lung cancer

Background: Genetic alterations activating the MAPK pathway are common in non-small cell lung cancer (NSCLC). Patients with NSCLC may benefit from treatment with the pan-RAF inhibitor naporafenib (LXH254) plus the ERK1/2 inhibitor rineterkib (LTT462) or MEK1/2 inhibitor trametinib. Methods: This first-in-human phase 1b dose-escalation/dose-expansion study investigated the combinations of naporafenib (50-350 mg once daily [QD] or 300-600 mg twice daily [BID]) with rineterkib (100-300 mg QD) in...

TP53 mutations and survival in ovarian carcinoma patients receiving first-line chemotherapy plus bevacizumab: Results of the MITO16A/MaNGO OV-2 study

To date, there are no biomarkers that define a patient subpopulation responsive to bevacizumab (BEV), an effective treatment option for advanced ovarian carcinoma (OC). In the context of the MITO16A/MaNGO OV-2 trial, a Phase IV study of chemotherapy combined with BEV in first-line treatment of advanced OC, we evaluated TP53 mutations by next-generation sequencing and p53 expression by immunohistochemistry (IHC) on 202 and 311 cases, respectively. We further correlated TP53 mutations in terms ...

Disruptions in antigen processing and presentation machinery on sarcoma

BackgroundThe antigen processing machinery (APM) plays a critical role in generating tumor-specific antigens that can be recognized and targeted by the immune system. Proper functioning of APM components is essential for presenting these antigens on the surface of tumor cells, enabling immune detection and destruction. In many cancers, defects in APM can lead to immune evasion, contributing to tumor progression and poor clinical outcomes. However, the status of the APM in sarcomas is not well...

A glia-enriched stem cell 3D model of the human brain mimics the glial-immune neurodegenerative phenotypes of multiple sclerosis

The role of central nervous system (CNS) glia in sustaining self-autonomous inflammation and driving clinical progression in multiple sclerosis (MS) is gaining scientific interest. We applied a single transcription factor (SOX10)-based protocol to accelerate oligodendrocyte differentiation from human induced pluripotent stem cell (hiPSC)-derived neural precursor cells, generating self-organizing forebrain organoids. These organoids include neurons, astrocytes, oligodendroglia, and hiPSC-deriv...

miR-128-3p Is a Novel Regulator of Vascular Smooth Muscle Cell Phenotypic Switch and Vascular Diseases

Rationale: MicroRNAs (miRNAs, miRs) are small noncoding RNAs that modulate gene expression by negatively regulating translation of target genes. Although the role of several miRNAs in vascular smooth muscle cells (VSMCs) has been extensively characterized, the function of miRNA-128-3p (miR-128) is still unknown. Objective: To determine if miR-128 modulates VSMC phenotype and to define the underlying mechanisms. Methods and Results: We screened for miRNAs whose expression is modulated by an al...

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Tipologia
  • 1 Contributo su Rivista24912
  • 4 Contributo in Atti di Convegno ...1863
  • 2 Contributo in Volume941
  • 3 Libro68
  • 8 Tesi di dottorato53
  • 6 Brevetti42
  • 5 Altro38
Rivista
  • DIGESTIVE AND LIVER DISEASE447
  • EUROPEAN JOURNAL OF NUCLEAR MEDIC...382
  • ANNALS OF ONCOLOGY307
  • THE JOURNAL OF NUCLEAR MEDICINE302
  • GASTROENTEROLOGY284
  • THE JOURNAL OF UROLOGY260
  • JOURNAL OF CLINICAL ONCOLOGY223
  • GASTROINTESTINAL ENDOSCOPY220
  • EUROPEAN JOURNAL OF CANCER192
  • ALLERGY184
Serie
  • METHODS IN MOLECULAR BIOLOGY4
  • ADVANCES IN EXPERIMENTAL MEDICINE...3
  • ANNUAL UPDATE IN INTENSIVE CARE A...2
  • IEEE ENGINEERING IN MEDICINE AND ...2
  • LECTURE NOTES IN COMPUTER SCIENCE2
  • HANDBOOK OF EXPERIMENTAL PHARMACO...1
  • MATHEMATICS AND VISUALIZATION1
  • METHODS IN MOLECULAR BIOLOGY1
  • SPRINGER SERIES ON FLUORESCENCE1
  • UPDATES IN SURGERY SERIES1
Data di pubblicazione
  • In corso di stampa42
  • 2020 - 20246738
  • 2010 - 201913286
  • 2000 - 20095692
  • 1990 - 19991698
  • 1980 - 1989437
  • 1975 - 197924
Prodotti più visti
  • Serum anti-phospholipid antibody prevalence and cardiovascular significance in the general population of the camelia study
  • Vitreo-papillary adhesion as a prognostic factor in pseudo- and lamellar macular holes
  • Selective Infection of Antigen-Specific B Lymphocytes by Salmonella Mediates Bacterial Survival and Systemic Spreading of Infection
  • Healthcare organizational performance: why changing the culture really matters. Commentary
  • Living with Chronic Spontaneous Urticaria in Italy: A Narrative Medicine Project to Improve the Pathway of Patient Care
  • Biological agents for ulcerative colitis : Hypes and hopes
  • Multi-strain Symbiotic Preparations as a Novel Adjuvant Approach to Allergic Rhinitis
  • Probiotics as a Novel Adjuvant Approach to Atopic Dermatitis
  • Atlante di Topografia Corneale
  • Vascular endothelial growth factor C disrupts the endothelial lymphatic barrier to promote colorectal cancer invasion
Prodotti più scaricati
  • Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials
  • Efficacy of Trunk Balance Exercises for Individuals With Chronic Low Back Pain: A Randomized Clinical Trial
  • Minimal morphological criteria for defining bone marrow dysplasia: a basis for clinical implementation of WHO classification of myelodysplastic syndromes
  • Type 2 Inflammation in Eosinophilic Esophagitis: From Pathophysiology to Therapeutic Targets
  • Patient-ventilator asynchrony in adult critically ill patients
  • Tidal volume challenge to predict fluid responsiveness in the operating room: An observational study
  • Is R1 vascular hepatectomy for hepatocellular carcinoma oncologically adequate? Analysis of 327 consecutive patients
  • Multimodality imaging of adult rhabdomyosarcoma: the added value of hybrid imaging
  • Cholangiocarcinoma Stem-like Subset Shapes Tumor-initiating Niche by Educating Associated Macrophages
  • Assessment of Fluid Responsiveness in Prone Neurosurgical Patients Undergoing Protective Ventilation: Role of Dynamic Indices, Tidal Volume Challenge, and End-Expiratory Occlusion Test

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