Home page

Ricerca

Aggiungi

Prodotti recenti

Single-Agent Divarasib (GDC-6036) in Solid Tumors with a KRAS G12C Mutation

Background: Divarasib (GDC-6036) is a covalent KRAS G12C inhibitor that was designed to have high potency and selectivity. Methods: In a phase 1 study, we evaluated divarasib administered orally once daily (at doses ranging from 50 to 400 mg) in patients who had advanced or metastatic solid tumors that harbor a KRAS G12C mutation. The primary objective was an assessment of safety; pharmacokinetics, investigator-evaluated antitumor activity, and biomarkers of response and resistance were also ...

Imaging Correlates between Headache and Breast Cancer: An [18F]FDG PET Study

: This study aimed to examine brain metabolic patterns on [18F]Fluorodeoxyglucose ([18F]FDG) positron emission tomography (PET) in breast cancer (BC), comparing patients with tension-type headache (TTH), migraine (MiG), and those without headache. Further association with BC response to neoadjuvant chemotherapy (NAC) was explored. In this prospective study, BC patients eligible for NAC performed total-body [18F]FDG PET/CT with a dedicated brain scan. A voxel-wise analysis (two-sample t-test) ...

Outcome after chimeric antigen receptor (CAR) T-cell therapy failure in large B-cell lymphomas

: This study retrospectively evaluated the outcome of salvage therapy in 51 patients who failed axicabtagene ciloleucel or tisagenlecleucel for relapsed/refractory large B-cell lymphomas. Of these patients, 22 (43%) were enrolled in clinical trials (glofitamab or loncastuximab tesirine + ibrutinib), whereas 29 received standard therapies (lenalidomide [Len], checkpoint inhibitors [CPIs], ibrutinib [I], chemoimmunotherapy and radiotherapy) or supportive care. Overall, 26 of 39 (67%) treated pa...

Heterogeneity of TPIT expression in ACTH-secreting extra-pituitary neuroendocrine tumors (NETs) supports the existence of different cellular programs in pancreatic and pulmonary NETs

: Extra-pituitary ACTH secretion is associated with a variety of neoplastic conditions and may cause the so-called ectopic ACTH-dependent Cushing syndrome (CS). The clarification of the mechanisms of extra-pituitary ACTH expression would provide potential therapeutic targets for this complex and severe disease. In the adenohypophysis, the transcription factor TPIT, co-operating with other molecules, induces POMC expression and ACTH production. However, no data are currently available on the p...

Therapeutic Strategies for COVID-19 Lung Disease in Children

: The novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection has milder presentation in children than in adults, mostly requiring only supportive therapy. The immunopathogenic course of COVID-19 can be divided in two distinct but overlapping phases: the first triggered by the virus itself and the second one by the host immune response (cytokine storm). Respiratory failure or systemic involvement as Multisystem Inflammatory Syndrome in Children (MIS-C) requiring intensive...

Scopri

Prodotti più visti

Vitreo-papillary adhesion as a prognostic factor in pseudo- and lamellar macular holes
Selective Infection of Antigen-Specific B Lymphocytes by Salmonella Mediates Bacterial Survival and Systemic Spreading of Infection
Healthcare organizational performance: why changing the culture really matters. Commentary
Biological agents for ulcerative colitis : Hypes and hopes
Multi-strain Symbiotic Preparations as a Novel Adjuvant Approach to Allergic Rhinitis
Probiotics as a Novel Adjuvant Approach to Atopic Dermatitis
SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts
Vascular endothelial growth factor C disrupts the endothelial lymphatic barrier to promote colorectal cancer invasion
Multimodal treatment of perianal fistulas in Crohn's disease: seton versus anti-TNF versus advancement plasty (PISA): study protocol for a randomized controlled trial
Skeletal muscle regenerative approach combining stem cells and 3D bioprinting

Prodotti più scaricati

Efficacy of Trunk Balance Exercises for Individuals With Chronic Low Back Pain: A Randomized Clinical Trial
Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials
Healthcare organizational performance: why changing the culture really matters. Commentary
Patient-ventilator asynchrony in adult critically ill patients
Invasive arterial pressure monitoring: much more than mean arterial pressure!
Minimal morphological criteria for defining bone marrow dysplasia: a basis for clinical implementation of WHO classification of myelodysplastic syndromes
Multimodality imaging of adult rhabdomyosarcoma: the added value of hybrid imaging
A Natural Language Processing-Based Virtual Patient Simulator and Intelligent Tutoring System for the Clinical Diagnostic Process: Simulator Development and Case Study
State-of-the-art of FAPI-PET imaging: a systematic review and meta-analysis
Type 2 Inflammation in Eosinophilic Esophagitis: From Pathophysiology to Therapeutic Targets

Esplora il catalogo della ricerca

CINECA IRIS Institutial research information system

Ricerca

Prodotti recenti

Single-Agent Divarasib (GDC-6036) in Solid Tumors with a KRAS G12C Mutation

Imaging Correlates between Headache and Breast Cancer: An [18F]FDG PET Study

Outcome after chimeric antigen receptor (CAR) T-cell therapy failure in large B-cell lymphomas

Heterogeneity of TPIT expression in ACTH-secreting extra-pituitary neuroendocrine tumors (NETs) supports the existence of different cellular programs in pancreatic and pulmonary NETs

Therapeutic Strategies for COVID-19 Lung Disease in Children

Scopri

Tipologia

Rivista

Serie

Data di pubblicazione

Prodotti più visti

Prodotti più scaricati

22.677

pubblicazioni

266

open-access

6.957

downloads

1.554

fulltext

185

autori