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Real-world effectiveness of mepolizumab in asthma: a systematic review and meta-analysis

Objective Exacerbations and suboptimal disease control are common in severe asthma with an eosinophilic phenotype (SAep). Mepolizumab, an anti-interleukin-5 monoclonal antibody, has demonstrated efficacy and safety in randomized controlled trials (RCTs). We aimed to strengthen the real-world evidence base for mepolizumab in SAep. Methods We analyzed data from Italian participants of REALITI-A, a global, real-world, prospective, observational study (primary outcome: rate of clinically signific...

Hypersensitivity Reactions to Iodinated Contrast Media: A Narrative Review of Current Evidence and Clinical Challenges

: Background/Objectives: Hypersensitivity reactions (HSRs) to iodinated contrast media (ICM), both immediate and non-immediate, pose clinical challenges despite using low-osmolality agents. This review aims to summarize current diagnostic approaches, cross-reactivity patterns, and the debated role of premedication. Methods: A narrative review was conducted using PubMed (2014-2024), selecting studies on ICM-related HSRs, focusing on skin and in vitro testing, drug provocation tests (DPTs), cro...

ARIA–Italy managing allergic rhinitis and asthma in a changing world: The role of the Pharmacist

Allergic rhinitis (AR) and asthma are common respiratory disorders that often occur together, affecting quality of life and increasing healthcare expenses of patients. These chronic illnesses are often managed without medical supervision, creating distinct challenges. A lack of resources can limit regular follow-up, which in turn promotes disease mismanagement and an increased reliance on self-medication, including the inappropriate use of corticosteroids and nasal decongestants. Community ph...

Oral Immunotherapy with Standardized Peanut Extract: A Game-Changer for Peanut Allergy

Peanut allergy is a persistent and potentially life-threatening condition affecting millions worldwide, necessitating effective therapeutic strategies beyond strict avoidance. Oral immunotherapy (OIT) has emerged as a promising approach, with peanut (Arachis hypogaea) allergen powder dnfp (Palforzia Aimmune therapeutics Brisbane Calif]) being the first FDA-approved standardized OIT for peanut allergy. This review synthesizes current clinical evidence on PTAH (peanut-tolerant Arachis hypogea),...

Vocal biomarkers correlate with FEV1 variations during methacholine challenge

Background: Mobile health applications are increasingly valued for their role in asthma management and the opportunity for large dataset collection. Our study aimed to investigate the feasibility of applying signal-processing and machine-learning technologies to detect alterations in the lower airway caliber and develop a machine-learning algorithm to identify changes in vocal biomarkers and detect bronchoconstriction in patients with airway hyperreactivity. Methods: This is an explorative ob...

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Tipologia
  • 1 Contributo su Rivista26901
  • 4 Contributo in Atti di Convegno ...1891
  • 2 Contributo in Volume954
  • 8 Tesi di dottorato91
  • 3 Libro68
  • 5 Altro56
  • 6 Brevetti42
Rivista
  • DIGESTIVE AND LIVER DISEASE458
  • EUROPEAN JOURNAL OF NUCLEAR MEDIC...396
  • ANNALS OF ONCOLOGY316
  • THE JOURNAL OF NUCLEAR MEDICINE304
  • GASTROENTEROLOGY289
  • THE JOURNAL OF UROLOGY266
  • JOURNAL OF CLINICAL ONCOLOGY234
  • GASTROINTESTINAL ENDOSCOPY231
  • CANCERS209
  • PLOS ONE208
Serie
  • ADVANCES IN EXPERIMENTAL MEDICINE...4
  • METHODS IN MOLECULAR BIOLOGY4
  • IEEE ENGINEERING IN MEDICINE AND ...3
  • ANNUAL UPDATE IN INTENSIVE CARE A...2
  • LECTURE NOTES IN COMPUTER SCIENCE2
  • HANDBOOK OF EXPERIMENTAL PHARMACO...1
  • MATHEMATICS AND VISUALIZATION1
  • METHODS IN MOLECULAR BIOLOGY1
  • SPRINGER SERIES ON FLUORESCENCE1
  • UPDATES IN SURGERY SERIES1
Data di pubblicazione
  • In corso di stampa17
  • 2020 - 20258396
  • 2010 - 201913598
  • 2000 - 20095802
  • 1990 - 19991724
  • 1980 - 1989442
  • 1975 - 197924
Prodotti più visti
  • Tips to optimize digital education in ophthalmology: Results from ESASO survey
  • Serum anti-phospholipid antibody prevalence and cardiovascular significance in the general population of the camelia study
  • Vitreo-papillary adhesion as a prognostic factor in pseudo- and lamellar macular holes
  • Selective Infection of Antigen-Specific B Lymphocytes by Salmonella Mediates Bacterial Survival and Systemic Spreading of Infection
  • Healthcare organizational performance: why changing the culture really matters. Commentary
  • Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
  • Living with Chronic Spontaneous Urticaria in Italy: A Narrative Medicine Project to Improve the Pathway of Patient Care
  • Atlante di Topografia Corneale
  • Disfunzione cognitiva post-operatoria nell’ anziano sottoposto a chirurgia in anestesia generale
  • Multi-strain Symbiotic Preparations as a Novel Adjuvant Approach to Allergic Rhinitis
Prodotti più scaricati
  • Derazantinib (ARQ 087) in advanced or inoperable FGFR2 gene fusion-positive intrahepatic cholangiocarcinoma
  • Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials
  • TNM 8th edition in thyroid cancer staging: is there an improvement in predicting recurrence?
  • Minimal morphological criteria for defining bone marrow dysplasia: a basis for clinical implementation of WHO classification of myelodysplastic syndromes
  • Efficacy of Trunk Balance Exercises for Individuals With Chronic Low Back Pain: A Randomized Clinical Trial
  • Type 2 Inflammation in Eosinophilic Esophagitis: From Pathophysiology to Therapeutic Targets
  • Patient-ventilator asynchrony in adult critically ill patients
  • Tidal volume challenge to predict fluid responsiveness in the operating room: An observational study
  • Is R1 vascular hepatectomy for hepatocellular carcinoma oncologically adequate? Analysis of 327 consecutive patients
  • Mini fluid chAllenge aNd End-expiratory occlusion test to assess flUid responsiVEness in the opeRating room (MANEUVER study): A multicentre cohort study

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