There are sex differences in vulnerability to Coronavirus disease 2019 (COVID-19). The coronavirus S protein mediates viral entry into target cells employing the host cellular serine protease TMPRSS2 for S-protein priming. The TMPRSS2 gene expression is responsive to androgen stimulation and it could partially explain sex differences. We hypothesized that men chronically exposed to 5-alpha reductase inhibitors (5ARIs) for benign prostate hyperplasia (BPH) have a lower risk of hospitalization for COVID-19.

Impact of chronic exposure to 5-alpha reductase inhibitors on the risk of hospitalization for COVID-19: a case-control study in male population from two COVID-19 regional centers of Lombardy (Italy)

Duga Stefano;Azzolini Elena;Buffi NicoloMaria;Lughezzani Giovanni;Paraboschi Elvezia;Cecconi Maurizio;Guazzoni Giorgio;Asselta Rosanna;Alessio Aghemo
Membro del Collaboration Group
;
Franca Barbic
Membro del Collaboration Group
;
Giovanni L Capretti;Angela Ceribelli
Membro del Collaboration Group
;
Maria De Santis
Membro del Collaboration Group
;
Giuseppe Ferrante;Andrea G Lania;Ana Lleo
Membro del Collaboration Group
;
Giovanni Lughezzani
Membro del Collaboration Group
;
Alberto Malesci
Membro del Collaboration Group
;
Gherardo Mazziotti
Membro del Collaboration Group
;
Fabio Procopio;Francesco Reggiani
Membro del Collaboration Group
;
Anna Stainer
Membro del Collaboration Group
;
Antonio Voza
Membro del Collaboration Group
;
Alberto Cremonesi
Membro del Collaboration Group
;
Carlo Selmi
Membro del Collaboration Group
;
Luca Viganò
Membro del Collaboration Group
;
2022

Abstract

There are sex differences in vulnerability to Coronavirus disease 2019 (COVID-19). The coronavirus S protein mediates viral entry into target cells employing the host cellular serine protease TMPRSS2 for S-protein priming. The TMPRSS2 gene expression is responsive to androgen stimulation and it could partially explain sex differences. We hypothesized that men chronically exposed to 5-alpha reductase inhibitors (5ARIs) for benign prostate hyperplasia (BPH) have a lower risk of hospitalization for COVID-19.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/61706
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? ND
social impact