Primary headaches are highly prevalent conditions that may burden individuals significantly. Their biological underpinnings are still not fully unveiled, yet the autonomic nervous system (ANS) arguably plays a significant role in the development and progression of these disorders. In this chapter, we will review the complex role of the ANS in migraine and cluster headache in the attack generation, clinical manifestations, interictal conditions, and the potential treatment effects of its iatrogenic modulation. Finally, we will discuss the evolutionary significance of primary headaches to provide a comprehensive bio-behavioural view to explain pain meaning and the distinctive autonomic-behavioural responses observed during migraine and cluster headache attacks.
Primary headaches and the autonomic nervous system
Pensato U.
2023-01-01
Abstract
Primary headaches are highly prevalent conditions that may burden individuals significantly. Their biological underpinnings are still not fully unveiled, yet the autonomic nervous system (ANS) arguably plays a significant role in the development and progression of these disorders. In this chapter, we will review the complex role of the ANS in migraine and cluster headache in the attack generation, clinical manifestations, interictal conditions, and the potential treatment effects of its iatrogenic modulation. Finally, we will discuss the evolutionary significance of primary headaches to provide a comprehensive bio-behavioural view to explain pain meaning and the distinctive autonomic-behavioural responses observed during migraine and cluster headache attacks.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
