Adjuvant Imatinib or Observation in Patients With Gastrointestinal Stromal Tumors With KIT Exon 9 Mutations

QuestionWhat is the association of adjuvant imatinib with recurrence-free and overall survival in patients with resected gastrointestinal stromal tumors (GISTs) harboring KIT exon 9 mutations?FindingsIn this international retrospective cohort study of 367 patients, adjuvant imatinib was associated with significantly longer recurrence-free and overall survival in the full cohort and among patients with modified National Institutes of Health criteria high-risk disease.MeaningThese findings supp...

Inguinal "neoligament" reconstruction after groin soft tissue sarcoma resection: A novel surgical technique

The Sacral Frame Technique: A Novel Trans/Extrasacral Approach for Giant Sacral Schwannomas Resection with Sacropelvic Biomechanics Preservation

Background: Giant sacral schwannomas present a significant surgical challenge, often requiring extensive resections that compromise neurological function and sacropelvic biomechanics. Conventional approaches frequently necessitate sacral bone sacrifice, resulting in the deafferentation of key pelvic stabilizers and subsequent long-term functional deficits. This study introduces the novel single-posterior "Sacral Frame Technique," designed to preserve the lateral sacral bone margin and optimiz...

Transiliac bone tunnel route for lower limb vascular reconstruction

Major oncovascular resections involving irradiated or infected groins often preclude standard in-line arterial or venous reconstruction because of hostile local conditions and high reinfection risk. In these complex scenarios, trans-iliac bone tunnel bypass (TIBB) represents an alternative extra-anatomic solution, providing a protected lateral route that avoids contaminated fields while ensuring durable limb perfusion or venous outflow. We describe the technical principles, perioperative mana...