Total marrow and (lymphoid) irradiation (TMI/TMLI) is a radiotherapy (RT) treatment that selectively irradiates the entire bone marrow and lymphatic system. TMI/TMLI is used in conditioning regimens before hematopoietic stem-cell transplantation for acute leukemia and multiple myeloma. Compared with traditional total body irradiation (TBI), where the entire body of the patient is irradiated, TMI/TMLI offers a targeted approach with reduced risk of toxicity and improved efficacy. This treatmen...
Cardiovascular diseases remain the leading cause of death globally, with coronary artery disease (CAD) being the primary contributor. The identification of high-risk plaques in coronary arteries, particularly non-flow-limiting lesions, is vital for improving risk stratification and reducing adverse cardiac events. This thesis investigates the application of novel imaging tools and artificial intelligence (AI) in evaluating vulnerable plaque characteristics, focusing on wall shear stress (WSS)...
Aim of the study Building a model to predict the pathological complete response (pCR) of breast cancer patients after neoadjuvant chemotherapy (NAC). Introduction Breast cancer (BC) remains the leading cause of cancer-related deaths among women worldwide. The treatment of BC is complex, with multiple strategies tailored to the tumor’s subtype, stage, and molecular characteristics. These strategies include adjuvant and neoadjuvant approaches. In the adjuvant setting, systemic therapies like ch...
The COVID-19 pandemic, caused by SARS-CoV-2, has posed significant global health challenges due to its complex pathogenesis and continuous emergence of new variants. This has made it necessary to develop prophylactic vaccines to achieve herd immunity. Beyond adaptive immunity, vaccines may also activate the innate immune system, contributing to the establishment of "trained immunity". Despite advances in understanding the adaptive immune response to SARS-CoV2, there is...