The chemokine system has key function in innate and adaptive immunity. Consisting of chemotactic cytokines(chemokines)and G-protein-coupled chemokine receptors, it governs the migration of immune cells during homeostasis and inflammation. Since the first report on a chemokine in 1987, the knowledge has extended to about 50 mammalian chemokines and 19 cognate receptors. In the present encyclopedic article, we summarize the available information on the chemokine system and its specific function in immune responses.
Function of chemokines and their receptors in Immunity
Uguccioni M
2016-01-01
Abstract
The chemokine system has key function in innate and adaptive immunity. Consisting of chemotactic cytokines(chemokines)and G-protein-coupled chemokine receptors, it governs the migration of immune cells during homeostasis and inflammation. Since the first report on a chemokine in 1987, the knowledge has extended to about 50 mammalian chemokines and 19 cognate receptors. In the present encyclopedic article, we summarize the available information on the chemokine system and its specific function in immune responses.File in questo prodotto:
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