Background: The increasing expertise in the field of transnasal endoscopic surgery has recently expanded its indications to include the sinonasal malignancies. We report our experience in the management of sinonasal adenoid cystic carcinoma (ACC) through an endoscopic endonasal approach. Materials and Methods: Retrospective analysis of patients affected by sinonasal ACC, treated through an endoscopic endonasal approach from 1998 to 2012, in two Italian tertiary referral centres. Results: The patients eligible for the present analysis were 28. The nasal fossa (46%), maxillary sinus (32%), nasal septum (15%), and sphenoid sinus (7%) were the primary tumor sites encountered. The majority of patients presented with locally advanced disease, without a systemic spreading. In 5 cases, the involvement of anterior skull base required a transnasal endoscopic craniectomy. Overall, 14/28 (50%) patients received some form of adjuvant radiotherapy. The follow-‐up ranges from 6 to 168 months (mean of 56 months). The 5-‐year overall, disease-‐specific, disease-‐free and recurrence-‐free survivals were 87.5%±8.98, 87.5%±8.98, 67.9%±11.6 and 69%±11.5, respectively. Conclusions: These results combined with short hospitalization time, due to a very limited morbidity typical of mini-‐invasive procedures, seem to indicate that endoscopic surgery, when properly planned and in expert hands, may be a valid alternative to standard surgical approaches for the management of this subset of sinonasal cancers.
Endoscopic endonasal resection of adenoid cystic carcinoma: our experience from a series of 28 cases
Ferreli F;
2014-01-01
Abstract
Background: The increasing expertise in the field of transnasal endoscopic surgery has recently expanded its indications to include the sinonasal malignancies. We report our experience in the management of sinonasal adenoid cystic carcinoma (ACC) through an endoscopic endonasal approach. Materials and Methods: Retrospective analysis of patients affected by sinonasal ACC, treated through an endoscopic endonasal approach from 1998 to 2012, in two Italian tertiary referral centres. Results: The patients eligible for the present analysis were 28. The nasal fossa (46%), maxillary sinus (32%), nasal septum (15%), and sphenoid sinus (7%) were the primary tumor sites encountered. The majority of patients presented with locally advanced disease, without a systemic spreading. In 5 cases, the involvement of anterior skull base required a transnasal endoscopic craniectomy. Overall, 14/28 (50%) patients received some form of adjuvant radiotherapy. The follow-‐up ranges from 6 to 168 months (mean of 56 months). The 5-‐year overall, disease-‐specific, disease-‐free and recurrence-‐free survivals were 87.5%±8.98, 87.5%±8.98, 67.9%±11.6 and 69%±11.5, respectively. Conclusions: These results combined with short hospitalization time, due to a very limited morbidity typical of mini-‐invasive procedures, seem to indicate that endoscopic surgery, when properly planned and in expert hands, may be a valid alternative to standard surgical approaches for the management of this subset of sinonasal cancers.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
