Background: Although the beta-blocker propranolol is considered one of the most effective tremor treatments and other beta-blockers are often prescribed to patients with tremor, those with partial beta-agonist activity on beta-adrenoreceptors can theoretically induce or exacerbate tremor. Here we report 2 patients with tremor induced or worsened by such beta-blockers. Cases: Case 1 is a 38-year-old man with worsening of tremor in both upper extremities after the introduction of pindolol as an adjunct treatment for severe depression. The tremor improved 1 month after discontinuing this medication. Case 2 is a 77-year-old woman with new bilateral hand tremor after receiving labetalol for the management of hypertension during a hospital admission. Tremor markedly attenuated after eliminating labetalol. Conclusion:beta-Blockers with partial agonist activity can induce or exacerbate tremor.
beta-Blocker-Induced Tremor
Fasano A
2021-01-01
Abstract
Background: Although the beta-blocker propranolol is considered one of the most effective tremor treatments and other beta-blockers are often prescribed to patients with tremor, those with partial beta-agonist activity on beta-adrenoreceptors can theoretically induce or exacerbate tremor. Here we report 2 patients with tremor induced or worsened by such beta-blockers. Cases: Case 1 is a 38-year-old man with worsening of tremor in both upper extremities after the introduction of pindolol as an adjunct treatment for severe depression. The tremor improved 1 month after discontinuing this medication. Case 2 is a 77-year-old woman with new bilateral hand tremor after receiving labetalol for the management of hypertension during a hospital admission. Tremor markedly attenuated after eliminating labetalol. Conclusion:beta-Blockers with partial agonist activity can induce or exacerbate tremor.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
