Recent advances have highlighted that antigen presentation in the gastrointestinal tract is carried out by different specialized immune and non-immune cells. This is required in order to achieve tolerance towards self and non-self harmless antigens and immunity towards pathogenic microorganisms. In this review we will discuss the role of different players in these responses, including dendritic cells, macrophages, B cells and basophils as professional antigen presenting cells (APCs), and stromal cells and epithelial cells as non-professional APCs. The interaction between these cell types is required for the dynamic regulation of the immune response. © 2009 Elsevier Ltd. All rights reserved.

Functional specialization of antigen presenting cells in the gastrointestinal tract

M. Rescigno
2010

Abstract

Recent advances have highlighted that antigen presentation in the gastrointestinal tract is carried out by different specialized immune and non-immune cells. This is required in order to achieve tolerance towards self and non-self harmless antigens and immunity towards pathogenic microorganisms. In this review we will discuss the role of different players in these responses, including dendritic cells, macrophages, B cells and basophils as professional antigen presenting cells (APCs), and stromal cells and epithelial cells as non-professional APCs. The interaction between these cell types is required for the dynamic regulation of the immune response. © 2009 Elsevier Ltd. All rights reserved.
animals; antigen-presenting cells; gastrointestinal tract; humans; immune tolerance; inflammation; t-lymphocytes; immunology; immunology and allergy
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11699/1161
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