Rapid prototyping of titania substrates with micro and nanofeatures is obtained by combining nanosphere lithography with supersonic cluster beam deposition on protein-functionalized glass supports. The proliferation and differentiation of PC12 cells were studied on these substrates. The facile control and modification of the substrate structure at the micro- and nanoscale allowed us to characterize the role of functional and structural features on neuritogenesis and to control this phenomenon by identifying the optimal topography.
Titolo: | Rapid prototyping of nano- and micro-patterned substrates for the control of cell neuritogenesis by topographic and chemical cues |
Autori: | |
Data di pubblicazione: | 2011 |
Rivista: | |
Handle: | http://hdl.handle.net/11699/14662 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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