Emerging evidence indicates that activation of microglia, the immune cells of the brain, is strictly associated to both secretion of soluble molecules and release of extracellular membrane vesicles (EMVs) into the pericellular space. Through these processes, microglia heavily influence brain cell functions, either propagating inflammation and causing damage to neurons or playing a supportive, neuroprotective role. In this review, we highlight the emerging concepts related to vesicular mechanisms of secretion operating in microglial cells, with the aim of dissecting how microglia communicate with other cell types within the brain microenvironment in health and disease.

Classical and unconventional pathways of vesicular release in microglia.

Furlan R;Matteoli M;
2013

Abstract

Emerging evidence indicates that activation of microglia, the immune cells of the brain, is strictly associated to both secretion of soluble molecules and release of extracellular membrane vesicles (EMVs) into the pericellular space. Through these processes, microglia heavily influence brain cell functions, either propagating inflammation and causing damage to neurons or playing a supportive, neuroprotective role. In this review, we highlight the emerging concepts related to vesicular mechanisms of secretion operating in microglial cells, with the aim of dissecting how microglia communicate with other cell types within the brain microenvironment in health and disease.
Extracellular membrane vesicles; Microglia; Vesicular pathways of release; Animals; Brain; Cell-Derived Microparticles; Cytoplasmic Vesicles; Interleukin-1beta; Secretory Pathway; Cellular and Molecular Neuroscience; Neurology
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11699/1627
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