Experimental studies on laboratory animals have generally shown that fat content of diet can modify the tumor yield, either by promoting carcinogenesis (total and n-6 fatty acids) or by protecting (n-3 fatty acids) for the development of carcinoma of the breast, prostate and colon. However most cohort studies do not confirm this finding. We reviewed epidemiological studies based on biological markers of fat intake. Dietary fat intake is reflected by the concentration of particular fatty acids in adipose tissue, triglycerides, phospholipids and cholesteryl esters fractions of serum, plasma or erythrocyte membranes and provide an independent measurement of dietary intake. The results are conflicting and do not support a clear conclusion on the role of dietary fat in human corcinogenesis. Thus, further investigations are needed before making nutritional recommendations on fat intake for cancer prevention.

Fat in food and the risks of cancer in humans: an overview of biochemical epidemiological research

Riboli E
2001-01-01

Abstract

Experimental studies on laboratory animals have generally shown that fat content of diet can modify the tumor yield, either by promoting carcinogenesis (total and n-6 fatty acids) or by protecting (n-3 fatty acids) for the development of carcinoma of the breast, prostate and colon. However most cohort studies do not confirm this finding. We reviewed epidemiological studies based on biological markers of fat intake. Dietary fat intake is reflected by the concentration of particular fatty acids in adipose tissue, triglycerides, phospholipids and cholesteryl esters fractions of serum, plasma or erythrocyte membranes and provide an independent measurement of dietary intake. The results are conflicting and do not support a clear conclusion on the role of dietary fat in human corcinogenesis. Thus, further investigations are needed before making nutritional recommendations on fat intake for cancer prevention.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/2271
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