Urinary incontinence and diarrhoea associated with the switch from oral to injectable risperidone

OBJECTIVE: Urgency, urinary incontinence and bowel disturbances are distressing side effects that have been observed during treatment with risperidone and other antipsychotics probably due to the receptor affinity profile. This occurrence can lead to poor compliance and therefore impair clinical outcome. METHOD: We report the case of a 50 year-old lady, who experienced urinary incontinence and diarrhoea, when switching from oral to injectable risperidone, which ceased when discontinuing the drug. Results and conclusions It should be taken into account that some side effects can be revealed when switching from oral to depot formulations due to non-compliance to orals; nevertheless dose-dependent mechanisms and individual metabolic variability must be considered when observing idiosyncratic reactions to drugs.