Objective. To investigate the effects of Lactobacillus acidophilus NCFM / Bifidobacterium lactis BL-04 / fructo-oligosaccharide and Lactobacillus plantarum LP01/ Lactobacillus paracasei LPC00 / fructo-oligosaccharide preparations in the routine clinical management of seasonal allergic rhinitis (SAR) and perennial allergic rhinitis (PAR), respectively. Materials and Methods. Seventy-six and fifty-one outpatients attending 36 Allergy Clinics in Italy with clinically documented allergic rhinitis consumed a symbiotic combination of Lactobacillus acidophilus NCFM / Bifidobacterium lactis BL-04/ fructo-oligosaccharide and Lactobacillus plantarum LP01/ Lactobacillus paracasei LPC00 / fructo-oligosaccharide over a period of 4 months. Data on Allergic Rhinitis and Impact on Asthma (ARIA) classification, nasal symptoms severity by Visual Analogical Scale (VAS), and concomitant use of corticosteroids and antihistamines drugs were collected after 2 and 4 months of treatment (T1 and T2 respectively). Results. After the treatment with two multi-strain symbiotic preparations a significant reduction between baseline evaluation (T0) and T1/T2 on total nasal symptoms and ARIA classification of rhinitis were observed. A significant decrease on VAS index at all time points of the treatment vs pre-treatment was detected for Lactobacillus plantarum / Lactobacillus paracasei symbiotic combination; significant decrease was observed for Lactobacillus acidophilus / Bifidobacterium lactis symbiotic combination between T0 and T1, while a further reduction at T2 did not reach statistical significance. In addition a decrease in consumption of orally-administered corticosteroids and antihistamines drugs was found. Conclusion. These data on the effect of Lactobacillus acidophilus NCFM/ Bifidobacterium lactis BL-04 / fructo-oligosaccharide and Lactobacillus plantarum LP01/ Lactobacillus paracasei LPC00 / fructo-oligosaccharide preparations support their potential positive effect in the routine clinical management of subjects with SAR and PAR, respectively. Future studies are warranted to confirm this potential beneficial effect.
Multi-strain Symbiotic Preparations as a Novel Adjuvant Approach to Allergic Rhinitis
Heffler E;
2014-01-01
Abstract
Objective. To investigate the effects of Lactobacillus acidophilus NCFM / Bifidobacterium lactis BL-04 / fructo-oligosaccharide and Lactobacillus plantarum LP01/ Lactobacillus paracasei LPC00 / fructo-oligosaccharide preparations in the routine clinical management of seasonal allergic rhinitis (SAR) and perennial allergic rhinitis (PAR), respectively. Materials and Methods. Seventy-six and fifty-one outpatients attending 36 Allergy Clinics in Italy with clinically documented allergic rhinitis consumed a symbiotic combination of Lactobacillus acidophilus NCFM / Bifidobacterium lactis BL-04/ fructo-oligosaccharide and Lactobacillus plantarum LP01/ Lactobacillus paracasei LPC00 / fructo-oligosaccharide over a period of 4 months. Data on Allergic Rhinitis and Impact on Asthma (ARIA) classification, nasal symptoms severity by Visual Analogical Scale (VAS), and concomitant use of corticosteroids and antihistamines drugs were collected after 2 and 4 months of treatment (T1 and T2 respectively). Results. After the treatment with two multi-strain symbiotic preparations a significant reduction between baseline evaluation (T0) and T1/T2 on total nasal symptoms and ARIA classification of rhinitis were observed. A significant decrease on VAS index at all time points of the treatment vs pre-treatment was detected for Lactobacillus plantarum / Lactobacillus paracasei symbiotic combination; significant decrease was observed for Lactobacillus acidophilus / Bifidobacterium lactis symbiotic combination between T0 and T1, while a further reduction at T2 did not reach statistical significance. In addition a decrease in consumption of orally-administered corticosteroids and antihistamines drugs was found. Conclusion. These data on the effect of Lactobacillus acidophilus NCFM/ Bifidobacterium lactis BL-04 / fructo-oligosaccharide and Lactobacillus plantarum LP01/ Lactobacillus paracasei LPC00 / fructo-oligosaccharide preparations support their potential positive effect in the routine clinical management of subjects with SAR and PAR, respectively. Future studies are warranted to confirm this potential beneficial effect.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
