The Dual Complexiy of PTX3 in Health and Disease: A Balancing Act?

Magrini, E; Mantovani, A; Garlanda, C

doi:10.1016/j.molmed.2016.04.007

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The humoral arm of innate immunity is complex and includes various molecules that serve as markers of inflammation with complementary characteristics, such as the short pentraxins C-reactive protein (CRP) and serum amyloid P (SAP) and the long pentraxin PTX3. There is a growing amount of evidence - including mouse and human genetics - that suggests that PTX3 is essential in conferring host resistance against selected pathogens and, moreover, that it plays a dual antagonistic role in the regulation of inflammation. Dissection of such a yin-and-yang role of pentraxins in immunity and inflammation is timely and significant as it may pave the way for better clinical exploitation against various diseases.

Titolo:	The Dual Complexiy of PTX3 in Health and Disease: A Balancing Act?
Autori:	Magrini E Mantovani A GARLANDA, CECILIA mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2016
Rivista:	TRENDS IN MOLECULAR MEDICINE
Abstract:	The humoral arm of innate immunity is complex and includes various molecules that serve as markers of inflammation with complementary characteristics, such as the short pentraxins C-reactive protein (CRP) and serum amyloid P (SAP) and the long pentraxin PTX3. There is a growing amount of evidence - including mouse and human genetics - that suggests that PTX3 is essential in conferring host resistance against selected pathogens and, moreover, that it plays a dual antagonistic role in the regulation of inflammation. Dissection of such a yin-and-yang role of pentraxins in immunity and inflammation is timely and significant as it may pave the way for better clinical exploitation against various diseases.
Handle:	http://hdl.handle.net/11699/3504
Appare nelle tipologie:	1.1 Articolo in rivista

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