Asthma is a heterogeneous chronic inflammatory disease in which different endotypes contribute to define clinical-inflammatory phenotypes. MicroRNAs (miRNAs) are a class of small, endogenous 22-25 nt RNA molecules that bind to specific mRNAs to inhibit translation and promote mRNA degradation. miRNAs function in post-transcriptional regulation and control physiological and pathological processes in various diseases. The purpose of this review is to summarize and discuss the current knowledge on the function of miRNAs in asthma, focusing the attention particularly on their biological properties, pathophysiologic roles, and potential use as biomarkers and/or therapies for asthma.
MicroRnas Profiling in Asthma: Potential Biomarkers and Therapeutic Targets.
Heffler E;
2017-01-01
Abstract
Asthma is a heterogeneous chronic inflammatory disease in which different endotypes contribute to define clinical-inflammatory phenotypes. MicroRNAs (miRNAs) are a class of small, endogenous 22-25 nt RNA molecules that bind to specific mRNAs to inhibit translation and promote mRNA degradation. miRNAs function in post-transcriptional regulation and control physiological and pathological processes in various diseases. The purpose of this review is to summarize and discuss the current knowledge on the function of miRNAs in asthma, focusing the attention particularly on their biological properties, pathophysiologic roles, and potential use as biomarkers and/or therapies for asthma.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
