RNAs not encoding proteins have gained prominence over the last couple of decades as fundamental regulators of cellular function. Not surprisingly, their dysregulation is increasingly being linked to pathology. Here, we review recent reports investigating the pathophysiological relevance of this species of RNA for the cardiovascular system, concentrating mainly on recent findings on long noncoding RNAs and microRNAs in cardiac hypertrophy and failure.

Long noncoding RNAs and microRNAs in cardiovascular pathophysiology

G. Condorelli
2015

Abstract

RNAs not encoding proteins have gained prominence over the last couple of decades as fundamental regulators of cellular function. Not surprisingly, their dysregulation is increasingly being linked to pathology. Here, we review recent reports investigating the pathophysiological relevance of this species of RNA for the cardiovascular system, concentrating mainly on recent findings on long noncoding RNAs and microRNAs in cardiac hypertrophy and failure.
Cardiac hypertrophy; Cardiac remodelling; Heart failure; lncRNAs; MicroRNAs; Myocardial infarction; Animals; Cardiovascular Diseases; Cardiovascular System; Gene Expression Regulation; Genetic Predisposition to Disease; Humans; Phenotype; RNA; Long Noncoding; Signal Transduction; Physiology; Cardiology and Cardiovascular Medicine; Medicine (all)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11699/3919
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