Anaplastic gliomas (AGs) are an extremely heterogeneous group of primary brain tumors. More recently, new discoveries have indicated that isocitrate dehydrogenase (IDH) mutation status is the most important parameter predicting survival. The primary aim of the present analysis was to identify prognostic factors, other than IDH status, that eventually impact survival.

Is IDH status the only factor predicting prognosis in newly diagnosed anaplastic glioma patients? Outcome evaluation and prognostic factor analysis in a single-institution large series

Pessina, Federico;Franzese, Ciro;Simonelli, Matteo;Politi, Letterio Salvatore;Santoro, Armando;Servadei, Franco;Scorsetti, Marta
2020-01-01

Abstract

Anaplastic gliomas (AGs) are an extremely heterogeneous group of primary brain tumors. More recently, new discoveries have indicated that isocitrate dehydrogenase (IDH) mutation status is the most important parameter predicting survival. The primary aim of the present analysis was to identify prognostic factors, other than IDH status, that eventually impact survival.
2020
AA = anaplastic astrocytoma
AG = anaplastic glioma
AO = anaplastic oligodendroglioma
AOA = anaplastic oligoastrocytoma
CE = contrast-enhanced
EOR = extent of resection
EORTC = European Organisation for Research and Treatment of Cancer
GBM = glioblastoma
GTR = gross-total resection
IDH = isocitrate dehydrogenase
KPS = Karnofsky Performance Scale
MGMT = O6-methylguanine-DNA-methyltransferase
NR = not reached
NTR = near-total resection
OS = overall survival
PCV = procarbazine, lomustine, and vincristine
PFS = progression-free survival
PR = partial resection
RTOG = Radiation Therapy Oncology Group
RTV = residual tumor volume
STR = subtotal resection
TMZ = temozolomide
anaplastic glioma
chemotherapy
oncology
prognostic factors
radiation therapy
surgery
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/51922
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