Adrenomyeloneuropathy (AMN) is the most frequent metabolic hereditary spastic paraplegia. Accordingly, its main site of pathological changes is the spinal cord. It is difficult to quantify AMN progression because commonly used clinical scales have limitations and reliable biomarkers are lacking. The goal was to investigate whether spinal cord and brain quantitative magnetic resonance imaging may assess structural changes in AMN over a relatively short time period.

Longitudinal quantitative MRI in adrenomyeloneuropathy

Politi L;
2019-01-01

Abstract

Adrenomyeloneuropathy (AMN) is the most frequent metabolic hereditary spastic paraplegia. Accordingly, its main site of pathological changes is the spinal cord. It is difficult to quantify AMN progression because commonly used clinical scales have limitations and reliable biomarkers are lacking. The goal was to investigate whether spinal cord and brain quantitative magnetic resonance imaging may assess structural changes in AMN over a relatively short time period.
2019
DWI
inherited metabolic disorders
leukodystrophies
spinal diseases
volumetric MRI
Adrenoleukodystrophy
Adult
Anisotropy
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
Disease Progression
Female
Follow-Up Studies
Humans
Longitudinal Studies
Magnetic Resonance Imaging
Male
Middle Aged
Pyramidal Tracts
Spinal Cord
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/5230
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