EUS-guided biopsy is the method of choice for obtaining pancreatic tissue. Next-generation sequencing (NGS) has been applied to EUS-guided biopsies and may classify patients based on specific molecular profiles. Our study aimed to compare side-by-side the diagnostic yield achievable by genetic identification of somatic mutations detected with NGS versus histological and cytological typing in locally advanced pancreatic carcinoma (LAPC) in samples acquired under EUS guidance.
Side-by-side comparison of next-generation sequencing, cytology, and histology in diagnosing locally advanced pancreatic adenocarcinoma
Soldà, Giulia;Maselli, Roberta;Malesci, Alberto;Repici, Alessandro
2020-01-01
Abstract
EUS-guided biopsy is the method of choice for obtaining pancreatic tissue. Next-generation sequencing (NGS) has been applied to EUS-guided biopsies and may classify patients based on specific molecular profiles. Our study aimed to compare side-by-side the diagnostic yield achievable by genetic identification of somatic mutations detected with NGS versus histological and cytological typing in locally advanced pancreatic carcinoma (LAPC) in samples acquired under EUS guidance.File in questo prodotto:
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