The current study investigates whether or not functional polymorphisms in the ATP-binding cassette transporter gene ABCG2 might affect gefitinib activity and/or toxicity in non-small-cell lung cancer (NSCLC) patients.

Impact of ABCG2 polymorphisms on the clinical outcome and toxicity of gefitinib in non-small-cell lung cancer patients

Zucali, Paolo A;Santoro, Armando;
2011-01-01

Abstract

The current study investigates whether or not functional polymorphisms in the ATP-binding cassette transporter gene ABCG2 might affect gefitinib activity and/or toxicity in non-small-cell lung cancer (NSCLC) patients.
2011
ATP Binding Cassette Transporter, Subfamily G, Member 2
ATP-Binding Cassette Transporters
Antineoplastic Agents
Carcinoma, Non-Small-Cell Lung
Diarrhea
Female
Gefitinib
Genome-Wide Association Study
Genotype
Haplotypes
Humans
Lung Neoplasms
Male
Middle Aged
Neoplasm Proteins
Polymorphism, Genetic
Precision Medicine
Quinazolines
Treatment Outcome
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/55281
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