Disruption of bile acid (BA) homeostasis plays a key role in intestinal inflammation. The gut-liver axis is the main site for the regulation of BA synthesis and BA pool size via the combined action of the nuclear Farnesoid X Receptor (FXR) and the enterokine Fibroblast Growth Factor 19 (FGF19). Increasing evidence have linked derangement of BA metabolism with dysbiosis and mucosal inflammation. Thus, here we aimed to investigate the potential action of an FGF19 analogue on intestinal microbiota and inflammation.

Fibroblast Growth Factor 19 modulates intestinal microbiota and inflammation in presence of Farnesoid X Receptor

Vetrano, Stefania;Danese, Silvio;
2020-01-01

Abstract

Disruption of bile acid (BA) homeostasis plays a key role in intestinal inflammation. The gut-liver axis is the main site for the regulation of BA synthesis and BA pool size via the combined action of the nuclear Farnesoid X Receptor (FXR) and the enterokine Fibroblast Growth Factor 19 (FGF19). Increasing evidence have linked derangement of BA metabolism with dysbiosis and mucosal inflammation. Thus, here we aimed to investigate the potential action of an FGF19 analogue on intestinal microbiota and inflammation.
2020
Bile acids
DSS-colitis
Enterokine
Intestinal inflammation
Nuclear receptors
Animals
Anti-Inflammatory Agents
Bile Acids and Salts
Colitis, Ulcerative
Crohn Disease
Female
Fibroblast Growth Factors
Humans
Male
Mice
Mice, Inbred C57BL
Peptides
Receptors, Cytoplasmic and Nuclear
Recombinant Proteins
Gastrointestinal Microbiome
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/56848
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