Cell type-specific and housekeeping enhancers and promoters collectively control the transcriptional output of mammalian cells. Recent data clarify how DNA sequence features on the one hand control functional coupling of promoters with selected enhancers, and on the other impart high level of activity to a broad range of regulatory elements.

Housekeeping and tissue-specific cis-regulatory elements: Recipes for specificity and recipes for activity

Natoli, Gioacchino;
2018

Abstract

Cell type-specific and housekeeping enhancers and promoters collectively control the transcriptional output of mammalian cells. Recent data clarify how DNA sequence features on the one hand control functional coupling of promoters with selected enhancers, and on the other impart high level of activity to a broad range of regulatory elements.
ETS
chromatin
core-promoters
enhancers
housekeeping genes
transcription
Animals
Chromatin
DNA
Genes, Essential
Humans
Enhancer Elements, Genetic
Promoter Regions, Genetic
Transcription, Genetic
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/59381
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