Previous studies reported an epidemiological association between CagA-positive H. pylori strains and pre-eclampsia. As antibodies anti-CagA cross-react with endothelial cells and trophoblast cells show an endothelial phenotypic profile, we hypothesized that anti-CagA antibodies may recognize antigens of cytotrophoblast cells, thus impairing their function.

Antibodies anti-CagA cross-react with trophoblast cells: a risk factor for pre-eclampsia?

Di Simone, Nicoletta;
2012-01-01

Abstract

Previous studies reported an epidemiological association between CagA-positive H. pylori strains and pre-eclampsia. As antibodies anti-CagA cross-react with endothelial cells and trophoblast cells show an endothelial phenotypic profile, we hypothesized that anti-CagA antibodies may recognize antigens of cytotrophoblast cells, thus impairing their function.
2012
Cross Reactions
Actins
Antibodies
Bacterial
Antigens
Bacterial
Bacterial Proteins
Cells
Cultured
Enzyme-Linked Immunosorbent Assay
Female
Fluorescent Antibody Technique
Humans
Pre-Eclampsia
Pregnancy
Risk Factors
Trophoblasts
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/60101
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 11
  • ???jsp.display-item.citation.isi??? 42
social impact