Antibiotic exposure has been associated with worse outcomes with immune checkpoint inhibitors (ICIs) in cancer patients, likely due to disruption of the gut microbiome. Other commonly prescribed medications, such as proton pump inhibitors (PPIs) and histamine-2-receptor antagonists (H2RAs), are also known to disrupt the microbiome, but data on their association with ICI outcomes are conflicting.

Antacid exposure and immunotherapy outcomes among patients with advanced hepatocellular carcinoma

Personeni, Nicola;Rimassa, Lorenza;
2021

Abstract

Antibiotic exposure has been associated with worse outcomes with immune checkpoint inhibitors (ICIs) in cancer patients, likely due to disruption of the gut microbiome. Other commonly prescribed medications, such as proton pump inhibitors (PPIs) and histamine-2-receptor antagonists (H2RAs), are also known to disrupt the microbiome, but data on their association with ICI outcomes are conflicting.
antacid
hepatocellular carcinoma
immunotherapy
proton pump inhibitor
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/60123
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