Purpose of reviewThe aim of the article is to highlight the association between alpha 1-antitrypsin deficiency (AATD) and asthma.Recent findingsAATD is one of the most common and underrecognized autosomal disorders associated with an increased risk of developing liver and lung diseases. An association between alpha 1-antitrypsin and asthma has been suggested, especially with severe forms of this disease. Many studies have shown an increased prevalence of asthma in the alpha 1-antitrypsin-deficient population overtime (4-38%). The biological mechanism underlying these two conditions and able to bind them has not yet been well investigated. As alpha 1-antitrypsin is the main inhibitor of the serine proteinase and it is an important anti-inflammatory protein with pronounced immunomodulatory activities, it can be hypothesized that the link between AATD and asthma might be represented by the elastase/antielastase imbalance and the proinflammatory effect that occurs because of the reduction of this protein.SummaryThere is a strong need for further researches to better understand the molecular mechanisms binding AATD and asthma. It is also recommendable to screen for AATD, late-onset asthma patients, and/or those with not fully reversible airways obstruction.

Alpha1-antitrypsin deficiency and asthma

Paoletti, Giovanni;Heffler, Enrico;
2021

Abstract

Purpose of reviewThe aim of the article is to highlight the association between alpha 1-antitrypsin deficiency (AATD) and asthma.Recent findingsAATD is one of the most common and underrecognized autosomal disorders associated with an increased risk of developing liver and lung diseases. An association between alpha 1-antitrypsin and asthma has been suggested, especially with severe forms of this disease. Many studies have shown an increased prevalence of asthma in the alpha 1-antitrypsin-deficient population overtime (4-38%). The biological mechanism underlying these two conditions and able to bind them has not yet been well investigated. As alpha 1-antitrypsin is the main inhibitor of the serine proteinase and it is an important anti-inflammatory protein with pronounced immunomodulatory activities, it can be hypothesized that the link between AATD and asthma might be represented by the elastase/antielastase imbalance and the proinflammatory effect that occurs because of the reduction of this protein.SummaryThere is a strong need for further researches to better understand the molecular mechanisms binding AATD and asthma. It is also recommendable to screen for AATD, late-onset asthma patients, and/or those with not fully reversible airways obstruction.
alpha 1-antitrypsin
alpha 1-antitrypsin deficiency
alpha 1-antitrypsin polymers
asthma
neutrophil asthma
phenoendotyping asthma
severe asthma
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/62098
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