Direct-acting antiviral (DAA) regimens provide a cure in >95% of patients with chronic HCV infection. However, in some patients in whom therapy fails, resistance-associated substitutions (RASs) can develop, limiting retreatment options and risking onward resistant virus transmission. In this study, we evaluated RAS prevalence and distribution, including novel NS5A RASs and clinical factors associated with RAS selection, among patients who experienced DAA treatment failure.

Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals

Cento, Valeria
Membro del Collaboration Group
2022

Abstract

Direct-acting antiviral (DAA) regimens provide a cure in >95% of patients with chronic HCV infection. However, in some patients in whom therapy fails, resistance-associated substitutions (RASs) can develop, limiting retreatment options and risking onward resistant virus transmission. In this study, we evaluated RAS prevalence and distribution, including novel NS5A RASs and clinical factors associated with RAS selection, among patients who experienced DAA treatment failure.
DAA
DAA, direct-acting antiviral
DCV, daclatasvir
DSV, dasabuvir
GT, genotype
HCV
LDV, ledipasvir
NI, nucleoside
NNI, non-nucleoside
NS5A
NS5AI, NS5A replication complex inhibitor
OR, odds ratio
PI, NS3 protease inhibitor
PIB, pibrentasvir
RAS
RASs, resistance-associated substitutions
SHARED, The Surveillance of Hepatitis C Antiviral Resistance, Epidemiology and methoDologies
SOF, sofosbuvir
SVR, sustained virologic response
VEL, velpatasvir
aOR, adjusted odds ratio
sFC, substitution frequency change
virologic failure
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11699/65872
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact