Rapid and reliable exclusion of invasive fungal infections (IFI) by markers able to avoid unnecessary empirical antifungal treatment is still a critical unmet clinical need. We investigated the diagnostic performance of a newly available β-d-Glucan (BDG) quantification assay, focusing on the optimisation of the BDG cut-off values for IFI exclusion.

Quantification of 1,3-β-d-glucan by Wako β-glucan assay for rapid exclusion of invasive fungal infections in critical patients: A diagnostic test accuracy study

Cento, Valeria;
2020-01-01

Abstract

Rapid and reliable exclusion of invasive fungal infections (IFI) by markers able to avoid unnecessary empirical antifungal treatment is still a critical unmet clinical need. We investigated the diagnostic performance of a newly available β-d-Glucan (BDG) quantification assay, focusing on the optimisation of the BDG cut-off values for IFI exclusion.
2020
antimycotic chemotherapy
candidaemia
deep fungal infection
immunodeficiency
peritonitis
surgery
systemic infection
Aged
Antifungal Agents
Caspofungin
Diagnostic Tests, Routine
Female
Fluconazole
Humans
Intensive Care Units
Invasive Fungal Infections
Limit of Detection
Male
Middle Aged
Predictive Value of Tests
Retrospective Studies
Sensitivity and Specificity
Voriconazole
beta-Glucans
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/65914
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