BACKGROUNDEndoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) is emerging as a complementary therapeutic approach for pancreatic solid masses. However, results of published data are difficult to interpret because of a retrospective design and small sample size.& nbsp;AIMTo systematically review data on EUS-RFA for solid lesions and to pool the results of the different experiences in order to provide more consistent evidence in terms of safety and efficacy.& nbsp;METHODSA comprehensive systematic literature search on the main databases was performed to identify articles in which patients with pancreatic solid lesions underwent EUS-RFA. The primary outcomes were procedure-related adverse events (AEs) and mortality. Secondary outcomes were the technical success rate and the effects on primary tumor growth. Statistical analyses were performed using Stata version 14.0.& nbsp;RESULTSIn total, 14 studies were included, with 120 patients undergoing 153 ablations of 129 solid pancreatic lesions. The STARmed technology was used in seven studies, the Habib system in six studies, and the HybridTherm probe in one study. The pooled technical success rate was 99.0% (I-2: 25.82%). The pooled overall AE rate was 8.0% (I-2: 11.46%). Excluding mild AEs, the pooled rates of serious AEs was 1.0% (I-2: 0%). No mortality related to the procedure was reported.& nbsp;CONCLUSIONThe present pooled analysis confirms the safety and feasibility of EUS-RFA.

Endoscopic ultrasound-guided ablation of solid pancreatic lesions: A systematic review of early outcomes with pooled analysis

Maselli, Roberta;Repici, Alessandro
2022

Abstract

BACKGROUNDEndoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) is emerging as a complementary therapeutic approach for pancreatic solid masses. However, results of published data are difficult to interpret because of a retrospective design and small sample size.& nbsp;AIMTo systematically review data on EUS-RFA for solid lesions and to pool the results of the different experiences in order to provide more consistent evidence in terms of safety and efficacy.& nbsp;METHODSA comprehensive systematic literature search on the main databases was performed to identify articles in which patients with pancreatic solid lesions underwent EUS-RFA. The primary outcomes were procedure-related adverse events (AEs) and mortality. Secondary outcomes were the technical success rate and the effects on primary tumor growth. Statistical analyses were performed using Stata version 14.0.& nbsp;RESULTSIn total, 14 studies were included, with 120 patients undergoing 153 ablations of 129 solid pancreatic lesions. The STARmed technology was used in seven studies, the Habib system in six studies, and the HybridTherm probe in one study. The pooled technical success rate was 99.0% (I-2: 25.82%). The pooled overall AE rate was 8.0% (I-2: 11.46%). Excluding mild AEs, the pooled rates of serious AEs was 1.0% (I-2: 0%). No mortality related to the procedure was reported.& nbsp;CONCLUSIONThe present pooled analysis confirms the safety and feasibility of EUS-RFA.
Cryotechnology
Endoscopic ultrasound
Habib
Neuroendocrine tumors
Pancreas
Pancreatic cancer
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/66141
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