Scarce drug penetration in solid tumours is one of the possible causes of the limited efficacy of chemotherapy and is related to the altered tumour microenvironment. The abnormal tumour extracellular matrix (ECM) together with abnormal blood and lymphatic vessels, reactive stroma and inflammation all affect the uptake, distribution and efficacy of anticancer drugs.

PEGylated recombinant human hyaluronidase (PEGPH20) pre-treatment improves intra-tumour distribution and efficacy of paclitaxel in preclinical models

D'Incalci, Maurizio;
2021

Abstract

Scarce drug penetration in solid tumours is one of the possible causes of the limited efficacy of chemotherapy and is related to the altered tumour microenvironment. The abnormal tumour extracellular matrix (ECM) together with abnormal blood and lymphatic vessels, reactive stroma and inflammation all affect the uptake, distribution and efficacy of anticancer drugs.
Drug distribution
Extracellular matrix
Hyaluronan
Mass spectrometry imaging
Solid tumours
Animals
Antineoplastic Agents, Phytogenic
Female
Humans
Hyaluronoglucosaminidase
Mice
Neoplasms
Paclitaxel
Tumor Microenvironment
Xenograft Model Antitumor Assays
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11699/67808
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