T cells exert a fundamental role in different autoimmune chronic inflammatory diseases. The low-affinity autoreactive T cell clones provide the first amplification loop after the antigen (AgX) presentation, and if not counterregulated by the T regulatory cells (Treg), they maintain the inflammation and predispose to organ damage. Interrupting the T cell amplification loop through calcineurin antagonists leads to maintenance of the whole process under the autoimmune threshold.

Rationale for T cell inhibition by cyclosporin A in major autoimmune diseases

De Santis, M
2005-01-01

Abstract

T cells exert a fundamental role in different autoimmune chronic inflammatory diseases. The low-affinity autoreactive T cell clones provide the first amplification loop after the antigen (AgX) presentation, and if not counterregulated by the T regulatory cells (Treg), they maintain the inflammation and predispose to organ damage. Interrupting the T cell amplification loop through calcineurin antagonists leads to maintenance of the whole process under the autoimmune threshold.
2005
Arthritis, Rheumatoid
Autoimmune Diseases
CD28 Antigens
Colitis, Ulcerative
Cyclosporine
Cytokines
Dermatomyositis
Humans
Immune Tolerance
Immunosuppressive Agents
Inflammation
Lupus Erythematosus, Systemic
T-Lymphocytes
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/68415
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