To analyze the association of interleukin (IL-1) gene polymorphisms with susceptibility to, and severity of, rheumatoid arthritis (RA) patients, comparing them with the genotype distribution in healthy controls. Also, to assess the influence of IL1-B and IL1RN gene polymorphism on IL-1beta/IL-1Ra plasma levels and response to therapy.

IL-1B and IL-1RN gene polymorphisms in rheumatoid arthritis: relationship with protein plasma levels and response to therapy

De Santis, Maria;
2006

Abstract

To analyze the association of interleukin (IL-1) gene polymorphisms with susceptibility to, and severity of, rheumatoid arthritis (RA) patients, comparing them with the genotype distribution in healthy controls. Also, to assess the influence of IL1-B and IL1RN gene polymorphism on IL-1beta/IL-1Ra plasma levels and response to therapy.
Adult
Aged
Alleles
Arthritis, Rheumatoid
Female
Humans
Interleukin 1 Receptor Antagonist Protein
Interleukin-1
Male
Methotrexate
Middle Aged
Polymorphism, Genetic
Sialoglycoproteins
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11699/68417
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