To investigate the relationship of the polymorphic enhancer HS1,2 central to the 3' enhancer complex regulatory region (IgH3'EC) of the immunoglobulin heavy chain genes with systemic sclerosis (SSc) disease and compare it with HLA-DR and DQ associations.

Polymorphism of immunoglobulin enhancer element HS1,2A: allele *2 associates with systemic sclerosis. Comparison with HLA-DR and DQ allele frequency

De Santis, M;
2007-01-01

Abstract

To investigate the relationship of the polymorphic enhancer HS1,2 central to the 3' enhancer complex regulatory region (IgH3'EC) of the immunoglobulin heavy chain genes with systemic sclerosis (SSc) disease and compare it with HLA-DR and DQ associations.
Adult
Aged
Autoantibodies
Esophagus
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
HLA-DQ Antigens
HLA-DR Antigens
Humans
Immunoglobulin Heavy Chains
Male
Middle Aged
Phenotype
Scleroderma, Systemic
Statistics, Nonparametric
Stomach
Enhancer Elements, Genetic
Polymorphism, Genetic
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/68420
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