Vascular endothelial growth factor (VEGF) is thought to play an important role in systemic sclerosis (SSc) pathogenesis. It was found to be upregulated in the serum and in the affected skin of scleroderma patients. However, its involvement in scleroderma lung disease is not clear. This study aimed to evaluate VEGF concentration in the bronchoalveolar lavage fluid (BALF) of scleroderma patients with interstitial lung disease, to correlate the cytokine levels in plasma and in the lung with pulmonary functional, radiological and cellular parameters, and with the progression of lung disease.

A vascular endothelial growth factor deficiency characterises scleroderma lung disease

De Santis, Maria;
2012

Abstract

Vascular endothelial growth factor (VEGF) is thought to play an important role in systemic sclerosis (SSc) pathogenesis. It was found to be upregulated in the serum and in the affected skin of scleroderma patients. However, its involvement in scleroderma lung disease is not clear. This study aimed to evaluate VEGF concentration in the bronchoalveolar lavage fluid (BALF) of scleroderma patients with interstitial lung disease, to correlate the cytokine levels in plasma and in the lung with pulmonary functional, radiological and cellular parameters, and with the progression of lung disease.
Bronchoalveolar Lavage Fluid
Enzyme-Linked Immunosorbent Assay
Female
Humans
Lung Diseases, Interstitial
Male
Middle Aged
Real-Time Polymerase Chain Reaction
Scleroderma, Systemic
Vascular Endothelial Growth Factor A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11699/68437
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