The SARS-CoV-2 infection has been advocated as an environmental trigger for autoimmune diseases, and a paradigmatic example comes from similarities between COVID-19 and the myositis-spectrum disease associated with antibodies against the melanoma differentiation antigen 5 (MDA5) in terms of clinical features, lung involvement, and immune mechanisms, particularly type I interferons (IFN).

Anti-MDA5 Antibody Linking COVID-19, Type I Interferon, and Autoimmunity: A Case Report and Systematic Literature Review

Ceribelli, Angela;Selmi, Carlo;De Santis, Maria
2022

Abstract

The SARS-CoV-2 infection has been advocated as an environmental trigger for autoimmune diseases, and a paradigmatic example comes from similarities between COVID-19 and the myositis-spectrum disease associated with antibodies against the melanoma differentiation antigen 5 (MDA5) in terms of clinical features, lung involvement, and immune mechanisms, particularly type I interferons (IFN).
COVID-19
anti-MDA5 syndrome
autoimmune disease
cytokines
immunology
inflammatory myositis
type I interferon signature
Antigens, Differentiation
Autoimmunity
Biomarkers
Humans
Interferon-Induced Helicase, IFIH1
SARS-CoV-2
Autoimmune Diseases
COVID-19
Interferon Type I
Melanoma
Myositis
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/68477
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