Anemia is one of the most common hematological manifestations in SLE patients, occurring in about 50% of active cases. STAT1 is a critical signaling molecule required for the production of type-1 interferon (I-IFN), CCL2, and CXCL10, all of which are upregulated in SLE. Overexpression of STAT1 has been described to be involved in anemia in animal models. The aim of this study is to analyze how these components are involved in SLE-associated anemia.

Positive correlation of STAT1 and miR-146a with anemia in patients with systemic lupus erythematosus

Ceribelli, Angela;
2014

Abstract

Anemia is one of the most common hematological manifestations in SLE patients, occurring in about 50% of active cases. STAT1 is a critical signaling molecule required for the production of type-1 interferon (I-IFN), CCL2, and CXCL10, all of which are upregulated in SLE. Overexpression of STAT1 has been described to be involved in anemia in animal models. The aim of this study is to analyze how these components are involved in SLE-associated anemia.
Adult
Age Factors
Anemia
Biomarkers
Chemokine CCL2
Chemokine CXCL10
Female
Humans
Lupus Erythematosus, Systemic
Lupus Nephritis
Male
MicroRNAs
Middle Aged
Population Groups
STAT1 Transcription Factor
Severity of Illness Index
Young Adult
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/68505
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