Autoantibodies to cytoplasmic structures called rods and rings (RR) are primarily specific to patients with hepatitis C virus (HCV) infection treated with pegylated interferon-alpha/ribavirin (IFN/R). Our aim is to examine anti-RR antibodies specificity and correlation with the response to IFN/R therapy in two independent cohorts (US and Italy) of HCV patients.

Differential reactivity to IMPDH2 by anti-rods/rings autoantibodies and unresponsiveness to pegylated interferon-alpha/ribavirin therapy in US and Italian HCV patients

Ceribelli, Angela;
2013

Abstract

Autoantibodies to cytoplasmic structures called rods and rings (RR) are primarily specific to patients with hepatitis C virus (HCV) infection treated with pegylated interferon-alpha/ribavirin (IFN/R). Our aim is to examine anti-RR antibodies specificity and correlation with the response to IFN/R therapy in two independent cohorts (US and Italy) of HCV patients.
Antibody Specificity
Antiviral Agents
Autoantibodies
Cohort Studies
Hepatitis C
Humans
IMP Dehydrogenase
Interferon-alpha
Italy
Polyethylene Glycols
Recombinant Proteins
Ribavirin
Seroepidemiologic Studies
Treatment Outcome
United States
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11699/68511
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