Anti-RNA polymerase III (RNAP III) antibodies are highly specific markers of scleroderma (systemic sclerosis, SSc) and associated with a rapidly progressing subset of SSc. The clinical presentation of anti-RNAP III positive patients, onset of Raynaud's phenomenon (RP) and SSc in unselected patients in a rheumatology clinic were evaluated.

Atypical clinical presentation of a subset of patients with anti-RNA polymerase III--non-scleroderma cases associated with dominant RNA polymerase I reactivity and nucleolar staining

Ceribelli, Angela;
2011

Abstract

Anti-RNA polymerase III (RNAP III) antibodies are highly specific markers of scleroderma (systemic sclerosis, SSc) and associated with a rapidly progressing subset of SSc. The clinical presentation of anti-RNAP III positive patients, onset of Raynaud's phenomenon (RP) and SSc in unselected patients in a rheumatology clinic were evaluated.
Adult
Aged
Autoantibodies
Autoantigens
Cell Nucleolus
Enzyme-Linked Immunosorbent Assay
Female
Fluorescent Antibody Technique
Humans
Middle Aged
RNA Polymerase I
RNA Polymerase III
Radioimmunoprecipitation Assay
Raynaud Disease
Scleroderma, Systemic
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/68522
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