Autoantibodies in the systemic rheumatic diseases are clinically useful biomarkers of the diagnosis or of certain clinical characteristics. An unusual pattern of immunoprecipitation, in which the D, E, F, and G proteins of small nuclear RNPs (snRNP) but without other components of the snRNP, was noticed at the autoantibody screening. The purpose of this study was to examine the target antigens and clinical manifestations associated with this specificity.

Autoantibodies to survival of motor neuron complex in patients with polymyositis: immunoprecipitation of D, E, F, and G proteins without other components of small nuclear ribonucleoproteins

Ceribelli, Angela;
2011

Abstract

Autoantibodies in the systemic rheumatic diseases are clinically useful biomarkers of the diagnosis or of certain clinical characteristics. An unusual pattern of immunoprecipitation, in which the D, E, F, and G proteins of small nuclear RNPs (snRNP) but without other components of the snRNP, was noticed at the autoantibody screening. The purpose of this study was to examine the target antigens and clinical manifestations associated with this specificity.
Adult
Autoantibodies
Autoimmune Diseases
Blotting, Western
Female
Fluorescent Antibody Technique
Humans
Immunoprecipitation
Lupus Erythematosus, Systemic
Male
Middle Aged
Polymyositis
Ribonucleoproteins, Small Nuclear
SMN Complex Proteins
Scleroderma, Systemic
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11699/68529
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