Primary anti-phospholipid syndrome (PAPS) is an autoimmune condition defined by anti-phospholipid antibodies (aPL) and thrombotic or obstetric events. Some PAPS can evolve into systemic lupus erythematosus (SLE) during follow-up. Few studies systematically examined lupus autoantibodies and their clinical significance in PAPS. The aim of our study is to analyze the clinical and laboratory correlations with lupus-related autoantibodies, detected by immunoprecipitation (IP), a technique not yet systematically applied to investigate autoantibodies in this condition.

Anti-argonaute2 (Ago2/Su) and -Ro antibodies identified by immunoprecipitation in primary anti-phospholipid syndrome (PAPS)

Ceribelli, Angela;
2011

Abstract

Primary anti-phospholipid syndrome (PAPS) is an autoimmune condition defined by anti-phospholipid antibodies (aPL) and thrombotic or obstetric events. Some PAPS can evolve into systemic lupus erythematosus (SLE) during follow-up. Few studies systematically examined lupus autoantibodies and their clinical significance in PAPS. The aim of our study is to analyze the clinical and laboratory correlations with lupus-related autoantibodies, detected by immunoprecipitation (IP), a technique not yet systematically applied to investigate autoantibodies in this condition.
Adult
Animals
Antibodies, Antiphospholipid
Antibody Specificity
Antiphospholipid Syndrome
Argonaute Proteins
Autoantibodies
Dogs
Enzyme-Linked Immunosorbent Assay
Eukaryotic Initiation Factor-2
Female
Humans
Immunoprecipitation
Lupus Erythematosus, Systemic
Male
Mice
Middle Aged
Rabbits
Ribonucleoproteins
Young Adult
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11699/68531
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