Patients with scleroderma (systemic sclerosis; SSc) can be classified into subsets based on autoantibody profile and clinical features. Specificities such as anti-Th/To and anti-fibrillarin (U3RNP) are detectable mainly by immunoprecipitation (IP), which is not widely used in clinical laboratories. We examined the autoantibody profiles and clinical manifestations in a cohort of Italian patients with SSc, focusing on anti-Th/To and anticentromere (ACA) antibodies, associated with limited cutaneous SSc (lcSSc).

Anti-Th/To are common antinucleolar autoantibodies in Italian patients with scleroderma

Ceribelli, Angela;
2010

Abstract

Patients with scleroderma (systemic sclerosis; SSc) can be classified into subsets based on autoantibody profile and clinical features. Specificities such as anti-Th/To and anti-fibrillarin (U3RNP) are detectable mainly by immunoprecipitation (IP), which is not widely used in clinical laboratories. We examined the autoantibody profiles and clinical manifestations in a cohort of Italian patients with SSc, focusing on anti-Th/To and anticentromere (ACA) antibodies, associated with limited cutaneous SSc (lcSSc).
Adult
Aged
Antibodies, Antinuclear
Autoantibodies
Cell Nucleolus
Female
Humans
Italy
Male
Middle Aged
Scleroderma, Systemic
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/68532
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