The aim of this study was to assess the prognostic value of tumor volume in oropharyngeal squamous cell carcinoma (OPSCC). The study was performed according to the PRISMA guidelines. A total of 1417 patients with a median age of 59.3 years (IQR 57.5-60) were included. The combined Hazard Ratios (HRs) for overall survival (OS) were 1.02 (95% CI, 0.99-1.05; p = 0.21) for primary tumor volume (pTV) and 1.01 (95% CI, 1.00-1.02; p = 0.15) for nodal tumor volume (nTV). Regarding locoregional control (LRC), the pooled HRs were 1.07 (95% CI, 0.99-1.17; p = 0.10) for pTV and 1.02 (95% CI, 1.01-1.03; p < 0.05) for nTV. Finally, the pooled HRs for disease-free survival (DFS) were 1.01 (95% CI, 1.00-1.03; p < 0.05) for pTV and 1.02 (95% CI, 1.01-1.03; p < 0.05) for nTV. In conclusion, pTV and nTV seem not to behave as reliable prognostic factors in OPSCC.

Does Tumor Volume Have a Prognostic Role in Oropharyngeal Squamous Cell Carcinoma? A Systematic Review and Meta-Analysis

Ferreli, Fabio;Franzese, Ciro;Scorsetti, Marta;Mercante, Giuseppe;Spriano, Giuseppe;De Virgilio, Armando
2022

Abstract

The aim of this study was to assess the prognostic value of tumor volume in oropharyngeal squamous cell carcinoma (OPSCC). The study was performed according to the PRISMA guidelines. A total of 1417 patients with a median age of 59.3 years (IQR 57.5-60) were included. The combined Hazard Ratios (HRs) for overall survival (OS) were 1.02 (95% CI, 0.99-1.05; p = 0.21) for primary tumor volume (pTV) and 1.01 (95% CI, 1.00-1.02; p = 0.15) for nodal tumor volume (nTV). Regarding locoregional control (LRC), the pooled HRs were 1.07 (95% CI, 0.99-1.17; p = 0.10) for pTV and 1.02 (95% CI, 1.01-1.03; p < 0.05) for nTV. Finally, the pooled HRs for disease-free survival (DFS) were 1.01 (95% CI, 1.00-1.03; p < 0.05) for pTV and 1.02 (95% CI, 1.01-1.03; p < 0.05) for nTV. In conclusion, pTV and nTV seem not to behave as reliable prognostic factors in OPSCC.
locoregional control
oropharyngeal cancer
squamous cell carcinoma
survival
tumor volume
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11699/68863
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