Olfactory training is the only evidence-based treatment for post viral olfactory dysfunction. Smell disorders after SARS-CoV-2 infection have been attributed to neuroinflammatory events within the olfactory bulb and the central nervous system. Therefore, targeting neuroinflammation is one potential strategy for promoting recovery from post-COVID-19 chronic olfactory dysfunction. Palmitoylethanolamide and luteolin (PEA-LUT) are candidate anti-inflammatory/ neuroprotective agents.

Ultramicronized Palmitoylethanolamide and Luteolin Supplement Combined with Olfactory Training to Treat Post-COVID-19 Olfactory Impairment: A Multi-Center Double-Blinded Randomized Placebo-Controlled Clinical Trial

Spriano, Giuseppe;Ferreli, Fabio;
2022

Abstract

Olfactory training is the only evidence-based treatment for post viral olfactory dysfunction. Smell disorders after SARS-CoV-2 infection have been attributed to neuroinflammatory events within the olfactory bulb and the central nervous system. Therefore, targeting neuroinflammation is one potential strategy for promoting recovery from post-COVID-19 chronic olfactory dysfunction. Palmitoylethanolamide and luteolin (PEA-LUT) are candidate anti-inflammatory/ neuroprotective agents.
COVID-19
Luteolin
PASC
PEA-LUT
SARS-CoV-2
Sniffin’ sticks
supplements
anosmia
anti-inflammatory
clinical trials
coronavirus
gustatory
hyposmia
long covid
neuroinflammation
neuroprotection
antioxidant
smell
olfaction
olfactory dysfunction
olfactory training
post-acute sequelae SARS-CoV-2 infection
post-viral
Palmitoylethanolamide
rehabilitation
quality of life
taste
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11699/68866
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