Our objective was to evaluate the non-germinal center (GC) profile as a marker for response and survivalin DLBCL and to compare the characteristics of patients with GC and non-GC DLBCL treated withrituximab-containing regimens. In this patient-level meta-analysis, retrospective data from 712 newlydiagnosed DLBCL patients treated with chemoimmunotherapy from 7 centers were analyzed. GC andnon-GC profiles were defined according to the Hans algorithm. Although the non-GC profile showed atrend towards worse overall survival (HR 1.24, 95% CI 0.92–1.66; p = 0.15) and progression-free survival(HR 1.29, 95% CI 0.96–1.73; p = 0.09), it did not retain its value in the multivariate survival analysis. Additionally,the non-GC profile was independently associated with worse complete response rates (OR 0.55,95% CI 0.37–0.83; p < 0.01) in the multivariate logistic regression analysis. Interestingly, Asian patientshad higher proportion of GC DLBCL (p = 0.01).©
The Hans algorithm is not prognostic in patients with diffuse large B-cell lymphoma treated with R-CHOP
UCCELLA, SILVIA;
2012-01-01
Abstract
Our objective was to evaluate the non-germinal center (GC) profile as a marker for response and survivalin DLBCL and to compare the characteristics of patients with GC and non-GC DLBCL treated withrituximab-containing regimens. In this patient-level meta-analysis, retrospective data from 712 newlydiagnosed DLBCL patients treated with chemoimmunotherapy from 7 centers were analyzed. GC andnon-GC profiles were defined according to the Hans algorithm. Although the non-GC profile showed atrend towards worse overall survival (HR 1.24, 95% CI 0.92–1.66; p = 0.15) and progression-free survival(HR 1.29, 95% CI 0.96–1.73; p = 0.09), it did not retain its value in the multivariate survival analysis. Additionally,the non-GC profile was independently associated with worse complete response rates (OR 0.55,95% CI 0.37–0.83; p < 0.01) in the multivariate logistic regression analysis. Interestingly, Asian patientshad higher proportion of GC DLBCL (p = 0.01).©I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
