Colchicine's medical evolution is historically bound to the Mediterranean basin, since remarkable researchers from this region underscored its valuable properties. With the passing of years colchicine became an essential pharmaceutical substance for the treatment of rheumatologic and cardiovascular diseases. In light of recent findings, the therapeutic value of colchicine has grown. In clinical practice, colchicine remains underutilized in view of its proven efficacy and safety. Its complex pharmacokinetics and multifaceted anti-inflammatory role remain under investigation. The current review addresses the safe administration of colchicine in view of key drug to drug interactions. Finally, we are briefly presenting colchicine's future potential applications.

Repurposing colchicine's journey in view of drug-to-drug interactions. A review

Stefanini, Giulio G;
2021-01-01

Abstract

Colchicine's medical evolution is historically bound to the Mediterranean basin, since remarkable researchers from this region underscored its valuable properties. With the passing of years colchicine became an essential pharmaceutical substance for the treatment of rheumatologic and cardiovascular diseases. In light of recent findings, the therapeutic value of colchicine has grown. In clinical practice, colchicine remains underutilized in view of its proven efficacy and safety. Its complex pharmacokinetics and multifaceted anti-inflammatory role remain under investigation. The current review addresses the safe administration of colchicine in view of key drug to drug interactions. Finally, we are briefly presenting colchicine's future potential applications.
ACS, acute coronary syndrome
CAD, coronary artery disease
COVID-19, coronavirus disease - 19
Colchicine
DOACs, direct oral anticoagulants
History
Inflammation
Lp-PLA2, Lipoprotein-associated phospholipase A2
NLRP3, NOD-, LRR- and pyrin domain-containing protein 3
Pharmacokinetics
ROCK, Rho-associated protein kinase
Repurposing
Safety
eGFR, estimated glomerular filtration rate
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/70164
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