We sought to investigate whether genetic effects on response to TNF inhibitors (TNFi) in rheumatoid arthritis (RA) could be localised by considering known genetic susceptibility loci for relevant traits and to evaluate the usefulness of these genetic loci for stratifying drug response.

Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39

Pitzalis, Costantino;
2019

Abstract

We sought to investigate whether genetic effects on response to TNF inhibitors (TNFi) in rheumatoid arthritis (RA) could be localised by considering known genetic susceptibility loci for relevant traits and to evaluate the usefulness of these genetic loci for stratifying drug response.
anti-tnf
pharmacogenetics
rheumatoid arthritis
Adult
Aged
Antigens, CD
Antirheumatic Agents
Apyrase
Arthritis, Rheumatoid
Biological Products
CD40 Antigens
Cohort Studies
Female
Gene Expression Regulation
Genome-Wide Association Study
Humans
Male
Middle Aged
Molecular Targeted Therapy
Multivariate Analysis
Predictive Value of Tests
Prognosis
Quantitative Trait Loci
Regression Analysis
Treatment Outcome
Tumor Necrosis Factor Inhibitors
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/70502
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