ELR+ CXC chemokines are heparin-binding cytokines signalling through the CXCR1 and CXCR2 receptors. ELR+ CXC chemokines have been associated with inflammatory arthritis due to their capacity to attract inflammatory cells. Here, we describe an unsuspected physiological function of these molecules in articular cartilage homeostasis.

A homeostatic function of CXCR2 signalling in articular cartilage

Pitzalis, Costantino;
2015-01-01

Abstract

ELR+ CXC chemokines are heparin-binding cytokines signalling through the CXCR1 and CXCR2 receptors. ELR+ CXC chemokines have been associated with inflammatory arthritis due to their capacity to attract inflammatory cells. Here, we describe an unsuspected physiological function of these molecules in articular cartilage homeostasis.
2015
Chemokines
Chondrocytes
Osteoarthritis
Animals
Apoptosis
Blotting, Western
Cartilage, Articular
Cells, Cultured
Chondrocytes
Disease Models, Animal
Homeostasis
Humans
Male
Mice
Mice, Inbred BALB C
Osteoarthritis
Receptors, Interleukin-8B
Signal Transduction
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/70507
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