To examine in a cohort of rheumatoid arthritis (RA) patients undergoing serial ultrasound (US)-guided biopsies of small joints in the context of clinical trials whether sufficient synovial tissue could be obtained at both baseline and second biopsy to: 1) accurately evaluate the synovial immune phenotype, 2) permit adequate RNA extraction to determine molecular signatures, and 3) sensitively detect change in the number of synovial sublining macrophages (CD68+) following effective therapy.

Use of ultrasound-guided small joint biopsy to evaluate the histopathologic response to rheumatoid arthritis therapy: recommendations for application to clinical trials

Pitzalis, Costantino
2015-01-01

Abstract

To examine in a cohort of rheumatoid arthritis (RA) patients undergoing serial ultrasound (US)-guided biopsies of small joints in the context of clinical trials whether sufficient synovial tissue could be obtained at both baseline and second biopsy to: 1) accurately evaluate the synovial immune phenotype, 2) permit adequate RNA extraction to determine molecular signatures, and 3) sensitively detect change in the number of synovial sublining macrophages (CD68+) following effective therapy.
Adult
Aged
Aged, 80 and over
Antigens, CD
Antigens, Differentiation, Myelomonocytic
Antirheumatic Agents
Arthritis, Rheumatoid
Biomarkers
Clinical Trials as Topic
Elbow Joint
Female
Humans
Image-Guided Biopsy
Macrophages
Male
Metacarpophalangeal Joint
Middle Aged
Phenotype
RNA
Sensitivity and Specificity
Treatment Outcome
Ultrasonography
Wrist Joint
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11699/70639
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